A helix is a type of smooth space curve, i.e. a curve in three-dimensional space. It has the property that the tangent line at any point makes a constant angle with a fixed line called the axis. Examples of helices are coil springs and the handrails of spiral staircases. A "filled-in" helix for example, a "spiral" (helical) ramp is called a helicoid. Helices are important in biology, as the DNA molecule is formed as two intertwined helices, and many proteins have helical substructures, known as alpha helices.

Helices can be either right-handed or left-handed. With the line of sight along the helix's axis, if a clockwise screwing motion moves the helix away from the observer, then it is called a right-handed helix; if towards the observer, then it is a left-handed helix. Handedness (or chirality) is a property of the helix, not of the perspective: a right-handed helix cannot be turned to look like a left-handed one unless it is viewed in a mirror, and vice versa.

Most hardware screw threads are right-handed helices. The alpha helix in biology as well as the A and B forms of DNA are also right-handed helices. The Z form of DNA is left-handed.

A conic helix may be defined as a spiral on a conic surface, with the distance to the apex an exponential function of the angle indicating direction from the axis. An example is the Corkscrew roller coaster at Cedar Point amusement park.

A curve is called a general helix or cylindrical helix if its tangent makes a constant angle with a fixed line in space. A curve is a general helix if and only if the ratio of curvature to torsion is constant.

Geometric pitch is the distance an element of an airplane propeller would advance in one revolution if it were moving along a helix having an angle equal to that between the chord of the element and a plane perpendicular to the propeller axis.

A curve is called a slant helix if its principal normal makes a constant angle with a fixed line in space. It can be constructed by applying a transformation to the moving frame of a general helix.